Nanna MacAulay
Rethinking hydrocephalus treatment – Pharmacological modulation of cerebrospinal fluid secretion?
Nanna MacAulay’s research field centres on the cerebrospinal fluid (CSF), in which the mammalian brain is bathed. The CSF is essential for normal brain function, but in many common pathologies, e.g., brain haemorrhage and hydrocephalus, the associated CSF dysregulation causes elevated intracranial pressure, leading to brain damage or even death. The current treatment of elevated intracranial pressure is limited to surgical approaches that are associated with severe complications.
The condition thus represents a towering, yet common, neurosurgical challenge, which has the potential to be partly resolved by pharmacological modulation of the CSF secretion. However, the knowledge gap in our understanding of the CSF secretion apparatus currently prevents such strategies. The project proposal aims at developing future pharmacological approaches to control brain fluid accumulation in pathology by determination of the origin and molecular mechanism of CSF secretion, the pathways underlying brain fluid accumulation in posthemorrhagic hydrocephalus, and how to manipulate these pathways therapeutically.
Article
Et af Danmarks største hjerneforskningsprogrammer uddeler i 2023 i alt 80 mio. kr. til projekter med potentiale til at ”fremme ny og...
