Kasper Munch
Moonlighting brain genes: Does gene expression in spermatogenesis shape the genetic basis of autism?
The prevalence of autism in Denmark has surged in the past decade, underscoring its significant societal impact. Accurate diagnosis and effective support will require a thorough understanding of its genetic basis. Previous studies have focused on the 22 chromosomes shared by males and females, neglecting the sex chromosomes. Many genes essential to neuro-development are also active in spermatogenesis. The project hypothesizes that selfish selection for transmission to live sperm promotes gene variants despite mildly detrimental effects on neuro-development. The project will quantify how such genes on the X chromosome contribute to the heritability of autism in males and females by analyzing the large Danish autism cohorts made available by the iPSYCH consortium.
