Luke Gamon

Protein dysfunction is a hallmark of neurodegenerative conditions like Parkinson’s and Alzheimer’s, characterized by specific chemical modifications on proteins (post-translational modifications or PTMs) such as phosphorylation, acetylation, nitration, and ubiquitinylation. This study aims to generate detailed maps of these modified proteins in the brains of rodents and humans affected by Parkinson’s and related diseases, with the goal of identifying new biomarkers or potential drug targets by unravelling the spatial dynamics and interactions of these proteins and their PTMs.