Erwin Schoof
Characterizing Cell Heterogeneity in Healthy and Malignant Blood Cells using Single Cell Proteomics
Erwin Schoof, Associate Professor, Technical University of Denmark, has received a fellowship totaling DKK 10 million from the Lundbeck Foundation.
How do individual blood cells determine their fate – and could we specifically target cancer stem cells in the clinic?
Erwin Schoof will utilize his Lundbeck Foundation Fellowship to create a research team aimed at addressing these questions.
His team will use a combination of experimental work and advanced computational analysis to discover key proteins within blood cells derived from healthy donors and Acute Myeloid Leukemia patients. He plans to use a novel method called single-cell proteomics by Mass Spectrometry (scp-MS) to map out the proteome landscapes of individual cells. By combining these with genetic blueprints (DNA and RNA), Erwin Schoof and his research group will establish integrated maps of cellular trajectories of the healthy and diseased blood system.
The work is a unique combination of big data, clinical samples and functional validation, and will provide unique insights into stem cell differentiation in the context of cancer.
