Nils Krietenstein
Cell-type-specific 3D chromatin organization – from chromatin domains to whole organs
Nils Krietenstein, associate professor at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (UCPH), has received a Fellowship from Lundbeck Foundation totalling DKK 10 million.
The research grant, to be paid out over a period of five years, enables Nils Krietenstein to establish his own research team at KU.
Nils Krietenstein, age 38, has developed a technique that makes it possible to study human chromatin folding in high-definition 3D.
Chromatin is the combination of DNA and protein that makes up the substance in a cell nucleus – and its folding is necessary for the nucleus in each cell to contain the enormous volumes of information stored in our DNA.
Nils Krietenstein will be examining this folding in detail to expand our understanding of how our DNA – our hereditary material – is expressed in different cell types. The aim is to study how noncoding mutations can contribute to the development of, for example, neurological disorders and cancer by changing the 3D organization of genomes.
