Thomas Graven-Nielsen
Brain neuro-adaptability to pain
Chronic pain is a major societal and economic burden, it affects one in five adults, and generally inadequate relief is offered. There is, therefore, a major unmet need for methods to predict susceptibility to chronic pain and more effective and mechanism-based pain treatments.
When an injury results in acute pain, the central nervous system produces a dynamic neuro-adaptive response. In this project, we will investigate 1) the neuro-adaptations to pain within the sensory, motor, cognitive-affective, and pain-regulating domain, and 2) whether these neuro-adaptations are linked via brain oscillatory activity as a fundamental mechanism. The hypothesis is that the interaction between pain-related neuro-adaptations may determine the severity of possible future chronic pain. We also hope the new knowledge can be used for more personal pain therapy by non-invasive brain stimulation to modulate the brain's oscillating activity. These studies will include healthy subjects as well as people with sub-acute and chronic pain.
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