Atox Bio Announces Appointment of Robert Greif as Chief Commercial Officer

 In this newly created position, Robert will be responsible for building the commercial organization and pre-commercial activities for Reltecimod, assuming the product is successfully developed and approved by regulatory authorities. Reltecimod is the company’s lead product in development and is currently in late stage clinical trials for Necrotizing Soft Tissue Infections (NSTI, “flesh eating bacteria”) and Sepsis-associated Acute Kidney Injury (AKI) with results of the ACCUTE, Phase 3 study in NSTI expected by year-end.

”Robert possesses in-depth knowledge in value-based commercialization, market access, and
specialty product launches for hospital-based therapies,” said Dan Teleman, Chief Executive
Officer of Atox Bio. “He is a key addition to the Atox Bio management team as we get closer to
completing the ACCUTE, Phase 3 study later this year. We look forward to benefitting from his
experience as we prepare to bring to market the first product specifically developed for treating
NSTI next year.”

Mr. Greif joins Atox Bio with a track record of leading high growth pharmaceutical and biotech
businesses. Most recently, Robert led all aspects of commercial operations at rEVO Biologics, an
orphan disease biotechnology company targeted at hospital-based hematology, hemophilia and
critical care communities. Prior to this, he worked for UnitedHealth Group as Senior Vice
President, Global Business Development. Before that, Mr. Greif held a variety of sales,
marketing and market access leadership roles at Boehringer Ingelheim and Sanofi where driving
demand and reimbursement in the commercial, government and hospital channels were integral to
the launch of various blockbuster products including Plavix, Flomax and Spiriva.

“I am impressed with the clinical development program for Reltecimod both for NSTI and AKI
and excited about the potential of bringing a new treatment to patients suffering from these
devastating diseases,” said Mr. Greif. “Joining Atox Bio at this pivotal moment of its
development offers a unique opportunity to be part of the team that will deliver its vision for the
benefit of patients.”

About Reltecimod

Reltecimod (AB103) is a rationally designed peptide that binds to the CD28 co-stimulatory
receptor and restores the host’s appropriate immune response to severe infections. By
modulating, but not inhibiting, the body’s acute inflammatory response, Reltecimod is designed
to help control the cytokine storm that could otherwise quickly lead to morbidity and mortality.

Reltecimod received Orphan Drug status from the FDA and EMA as well as Fast Track
designation for the NSTI indication. About Necrotizing Soft Tissue Infections (NSTI)
NSTI, commonly referred to as “flesh eating bacteria”, represent the most severe types of
infections involving soft tissues. NSTI progress rapidly and often result in significant tissue
destruction and systemic disease leading to multiple organ failure and death. NSTI are rare with
an estimated 28,000 patients annually in the US. Currently, there are no approved treatments for
NSTI. The standard of care includes prompt and repeated surgical debridement, aggressive
resuscitation and physiologic support, in addition to antibiotics.

About ACCUTE

The Phase 3 ACCUTE (AB103 Clinical Composite endpoint StUdy in necrotizing soft Tissue
infEctions) is an ongoing randomized, placebo-controlled study, that plans to enroll 290 patients
with NSTI at approximately 60 level 1 trauma sites in the US. Patients receive Reltecimod or
placebo, administered as a single dose during or shortly after surgical debridement, in addition to
standard of care treatment. The primary end point is a clinical composite that evaluates both the
local and systemic components of this disease.
About Acute Kidney Injury (AKI)
Acute Kidney Injury (AKI) involves inflammatory processes in the kidney which can lead to
permanent reduction of kidney function and is also associated with an increased risk of death,
extended hospitalization, and increased medical cost. There are currently no approved therapies to
treat AKI and the only treatment options are dialysis and supportive care.

About REAKT

The phase 2 REAKT (Reltecimod Efficacy for Acute Kidney Injury Trial) is an ongoing
randomized, placebo-controlled study, that plans enroll 120 patients with abdominal sepsis and
stage 2/3 AKI (as described by KDIGO criteria) at approximately 80 centers in the U.S and
Europe. Patients receive Reltecimod or placebo, administered as a single dose after the diagnosis
of AKI, in addition to standard of care treatment. The primary endpoint is complete recovery
from stage 2/3 AKI, defined as alive, free of dialysis and return of serum creatinine to <150% of
reference baseline.

About Atox Bio

Atox Bio is a late stage clinical company that develops novel immune modulators for critically ill
patients with severe infections. Atox Bio has an ongoing contract with the Biomedical Advanced
Research and Development Authority (BARDA) supporting the development of Reltecimod in
NSTI. Major investors in the company include SR One, OrbiMed, Lundbeckfonden Ventures,
Arix Bioscience plc and Adams Street Partners. The Company was established by Prof. Raymond Kaempfer and Dr. Gila Arad from the Hebrew University of Jerusalem and Yissum

Media Contact:

Tsipi Haitovsky
Global Media Liaison
Atox Bio
+972-52-598-9892
Tsipihai5@gmail.com