Kate Lykke Lambertsen is an associate professor of Neurobiology at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark and at the Department of Neurology, Odense University Hospital.
Her research interest is neuroinflammation with special focus on animal models of spinal cord injury, multiple sclerosis and stroke and the interface between basic and clinical neuroscience. Her research is focused on the roles of the central and peripheral immune responses to secondary neuronal cell death and how these can be manipulated in order to improve functional outcomes following injury to the CNS. Especially, she uses animal models to determine the role that inflammation plays following experimental stroke and spinal cord injury, with specific focus on cytokines and the contribution of resident microglia versus infiltrating leukocytes. Her work has helped define the cellular source(s) and the very different roles of the two forms (soluble and transmembrane) of the pleiotrophic cytokine tumor necorsis factor (TNF) and its receptors (TNFR1 and TNFR2) following injury to the CNS. With this work, her research supports recent publications demonstrating a neuroprotective role for the membrane-derived form of TNF, while the soluble form of TNF appears to sustain neuroinflammation.
Kate Lykke Lambertsen graduated as a MSc from the University of Southern Denmark in 1999. In 2004 she defended her PhD thesis entitled ”The patophysiological role of tumor necrosis factor and interferon gamma in focal cerebral ischemia in mice”. In 2005-2008 she did her first post doc funded by the Danish Medical Research Counsil at Medical Biotechnology Center, University of Southern Denmark. In 2008-2009 she was a post doc at the Miami Project to Cure Paralysis, in the laboratory headed by dr. John Bethea, funded by a grant from Carlsbergfondet. In 2009 she was appointed an associate professor at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark.